From the gastrointestinal tract: nausea, vomiting, diarrhea, pseudomembranous colitis.
From the side of hematopoiesis and hemostasis system: bleeding , anemia, reversible neutropenia (with prolonged use).
Laboratory findings: hypoprothrombinemia, increased prothrombin time, increased activity of “liver” transaminases and alkaline phosphatase, hypercreatininemia, positive Coombs’ test.
Local reactions: after intravenous injection – phlebitis; intramuscular npp injection – pain at the injection site.
Overdose Symptoms: an epileptic fit. The treatment: sedation with diazepam.
The interaction with other drugs
Pharmaceutically compatible with aminoglycosides (when the need for combination therapy cefoperazone and aminoglycoside drugs are administered in a sequential fractional intravenous drugs using two separate intravenous catheters). Indirect anticoagulants, heparin, thrombolytics, antiplatelet agents, increase the risk of hypoprothrombinemia, bleeding.
Aminoglycosides and “loop” diuretics increase the risk of nephrotoxicity, particularly in people with kidney failure.
Drugs that reduce the tubular secretion, increase the concentration of npp drug in the blood and slow down its excretion. Not compatible with ethanol development disulfiramopodobnyh reactions in the form of flushing, nausea, vomiting, headache, shortness of breath, tachycardia, decreased blood pressure, abdominal cramping.
can be used in combination therapy in combination with other antibiotics.
In cases of obstruction of the bile ducts, severe liver disease or concomitant renal dysfunction may be necessary to change the dosing regimen. In patients with impaired liver function and concomitant renal impairment is necessary to carry out monitoring of the concentration of drug in the blood serum. If not carried out to determine the concentration of the drug in serum, in these cases the dose should not exceed 2 g / day.
Long-term use can lead to the development of exciter stability. During the period of use of the drug may be a false positive reaction for glucose in the urine with a solution of Benedict or Fehling.
During treatment should refrain from receiving ethanol – possible effects, similar to the action of disulfiram (facial flushing, abdominal cramps and in the stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).
Patients who adhere to inadequate diet or with malabsorption of food (eg, cystic fibrosis), as well as patients who are in for a long time on parenteral nutrition, it may be deficient in npp. These patients should be monitored prothrombin time, and, if necessary, they It shows the assignment . In the application of cefoperazone (and other antibiotics) may develop superinfection, which requires discontinuation of the drug and appropriate treatment.
Powder for solution for intravenous and intramuscular administration of 1 g
1 g of the active substance in a sealed vial hermetically colorless transparent glass. The vial was sealed with a rubber stopper, an aluminum crimped cap. The aluminum cap is provided with a plastic cap for the control of the first opening. Each bottle with instruction on use is placed in npp a cardboard box.