The maximum concentration of sulbactam cefoperazone and after intravenous administration of 2 g of cefoperazone / sulbactam (1 g sulbactam, cefoperazone 1 g) for 5 min averaged 130.2 and 236.8 ug / ml, respectively. This reflects the higher volume of distribution of sulbactam as compared with that cefoperazone .
As sulbactam and cefoperazone is well distributed in various tissues and body fluids, including bile, gall bladder, skin, appendix, fallopian tubes, ovaries, uterus, and others. Sulbactam nandrolone phenylpropionate and cefoperazone cross the placental barrier.
Data on the presence of a pharmacokinetic interaction between sulbactam and cefoperazone when administered to cefoperazone / sulbactam not.
With repeated use of significant changes in the pharmacokinetics of both sulbactam / cefoperazone is not marked components. With the introduction of the drug every 8-12 hours accumulation was observed.
Approximately 84% of the dose, and 25% sulbactam cefoperazone dose, administered as a combination – cefoperazone / sulbactam, kidneys displayed. Most of the remaining dose of cefoperazone is excreted in the bile. Cefoperazone does not displace bilirubin from binding with plasma proteins. The half-life of sulbactam is an average of about 1 hour, cefoperazone – 1.7 h Serum nandrolone phenylpropionate is proportional to the administered dose..
If abnormal liver function
Cefoperazone is actively excreted in the bile. The half-life of cefoperazone is usually elongated and kidney excretion of the drug increased in patients with liver disease and / or obstruction of the biliary tract.Even with severe hepatic impairment in bile achieved therapeutic concentrations of cefoperazone, and elimination half-life only increased by 2-4 times.
If the kidney function
in patients with varying degrees of renal impairment treated with cefoperazone / sulbactam, revealed a high correlation between the total clearance of sulbactam from the body and calculated creatinine clearance. In patients with end-stage renal failure showed a significant nandrolone phenylpropionate extension of the half-life of sulbactam (mean 6.9 and 9.7 hours in various studies). Hemodialysis causes a significant change in half-life, total clearance and volume of distribution of sulbactam.
Application of the elderly
pharmacokinetics of cefoperazone / sulbactam was studied in elderly people with kidney failure, and impaired liver function. Compared with healthy volunteers showed an increase in the duration of half-life, decreased clearance and volume of distribution both increase sulbactam and cefoperazone. The pharmacokinetics of sulbactam correlated with the degree of renal dysfunction and the pharmacokinetics of cefoperazone – with the degree of liver dysfunction.
Use in children
The studies in children showed no significant changes in the pharmacokinetics of the components of cefoperazone / sulbactam compared to those in adults. The average half-life of sulbactam in children ranged from 0.91 to 1.42 hours, cefoperazone.
Infectious-inflammatory diseases, caused by susceptible microorganisms:
– infections of the upper and lower respiratory tract;
– an infection of the urinary system;
– peritonitis, cholecystitis, cholangitis;
– sepsis, meningitis
– infection of the skin nandrolone phenylpropionate and soft tissues
– bone and joint infections ;
– inflammatory diseases of the pelvic organs, including endometritis, gonorrhea.
Prevention of postoperative complications.