Following nandrolone side effects single intravenous doses of 0.5, 1 and 2 g of time to maximum concentration – 5 minutes, the maximal concentration of 39,101.7 and 214 ug / ml, respectively. After intramuscular injection at doses of 0.5 and 1 g of time to maximum concentration – 0.5 hours at 11 and 21 ug / ml, respectively. Relationship to plasma proteins – 30-50%. Bioavailability -. 90-95%
Generates therapeutic concentrations in most tissues (myocardium, bone, gall bladder, skin, soft tissue) and fluid (synovial, pericardial, pleural, phlegm, bile, urine, cerebrospinal fluid) of the body. The volume of distribution – 0.25-0.39 l / kg.
The when administered intravenously and 1-1.5 hours – when administered intramuscularly. Excreted by the kidneys – 20-36% unchanged, the rest – in the form of metabolites.
In chronic renal failure and the elderly half-life increased by 2 times. The half-life in newborns – 0.75-1.5 h, in preterm newborn infants (weight less than 1500 g) increases to 4.6 hours; in children weighing more than 1,500 grams -. 3.4 hours after repeated intravenous dose of 1 g every 6 hours for 14 days cumulation is not observed. Cefotaxime passes through the placenta and passes into breast milk.
The infectious-inflammatory diseases caused by susceptible organisms:
- infection of the central nervous system (meningitis),
- respiratory tract infections and upper respiratory tract,
- urinary tract infections,
- bone and joint infections,
- Skin and soft tissue infections,
- pelvic infection,
- gonorrhea nandrolone side effects,
- infected wounds and burns,
- abdominal infections,
- Lyme disease
- infections due to immune deficiency.
Prevention of infections after surgery (including urology, obstetrics and gynecology, gastro-intestinal tract).Contraindications:
Hypersensitivity (including to penicillins, other cephalosporins, carbapenems), pregnancy, child – up to 2.5 years (intramuscular injection).With care
during the nandrolone side effects neonatal period; chronic renal failure, ulcerative colitis (including history).
Pregnancy and lactation
Use of the drug is contraindicated during pregnancy.
Breast-feeding should be discontinued, if necessary, the appointment during lactation.
Dosing and Administration
The drug is administered intravenously (bolus or infusion), intramuscularly.
Adults and children weighing 50 kg or more: in uncomplicated infections, as well as urinary tract infections – intramuscular or intravenous injection, 1 g every 8-12 hours; with uncomplicated acute gonorrhea – intramuscular injection, 1 g once; at moderate infections – intramuscularly or intravenously at 1.2 g every 12 h; in severe infections, such as meningitis – intravenous injection, 2 g every 4-8 hours, maximum daily dose – ’12 Duration of treatment is determined individually.
In order to prevent the development of infections before surgery is administered during induction of general anesthesia, the single 1 If necessary, repeat administration after 612 hours.
When cesarean section – at the time of clipping in the umbilical vein – intravenous injection, 1 g, and then at 6 and 12 hours after the first dose – in addition to 1 g
When creatinine clearance 20 mL / min / 1.73 m 2 and less than the daily dose reduced by 2 times. Premature and newborn babies up nandrolone side effects to 1 week – intravenous injection, 50 mg / kg every 12 hours; aged 1 – 4 weeks – intravenous injection, 50 mg / kg every 8 hours; children weighing up to 50 kg – intramuscularly or intravenously (children over 2.5 years), 50-180 mg / kg 4-6 administrations. In severe infections, including meningitis, children the daily dose is increased to 100-200 mg / kg, intramuscularly or intravenously, in methods 4-6, the maximum daily dose – 12 g.