To prevent postoperative complications – 1 g or 2 g / in 30-90 minutes prior to surgery. The dose can be repeated every 12 hours, however, in most cases, for up to 24 hours.
In operations with an increased risk nandrolone of infection (eg, colorectal operations), or if the infection arising especially opasns (for example, open-heart operations or prosthetic joints) prophylactic use may continue for 72 hours after surgery zavershensh.
Patients with impaired renal function are usually prescribed daily dose (2-4 g) Patients whose glomerular filtration rate below 18 ml / min um serum creatinine greater than 3.5 mg / ml, the daily dose should not exceed 4 g
In patients with severe hepatic impairment, severe obstruction of the bile ducts daily dose should not exceed 2 years
In patients with renal hepatic insufficiency should be monitored cefoperazone concentration in the blood and adjust the dose if necessary.
In children the daily dose cefoperazone 50-200 mg / kg body weight, is administered in equal portions in two steps every 12 hours or longer if necessary. The maximum nandrolone daily dose of ’12
The on / in the introduction of the jet maximum single dose for children is 50 mg / kg. administration duration – at least 3-5 min. Newborns (<8 days) is administered 50-200 mg / kg of body weight per day in equal parts every 12 hours. Daily doses up to 300 mg / kg were used without complications in infants and children with severe infections, including bacterial meningitis.
The solvent may be used a 5% dextrose solution, isotonic sodium chloride solution (0.9%), sterile water for injection.
To prepare the solution for I / bolus needed to dissolve 1 g of cefoperazone in 10 ml of sterile water for injection or other compatible solution and administered for at least 3-5 min. For I / bolus cefoperazone maximum single dose for adult is 2 g, for children – 50 mg / kg body weight. When preparing a solution for / drip cefoperazone 1 g dissolved in 5 ml of sterile water for injection, the resulting solution was added to an infusion solution (Ringer’s lactate solution, 5% dextrose solution, isotonic sodium chloride solution) to nandrolone a concentration of 20-100 mg / ml . Duration of administration depending on the volume of the solution can vary from 10-30 minutes or more.
For the preparation of solutions designed for the / m injection, can be used sterile water for injection or isotonic sodium chloride solution. To 0.5 g dilution, use 2 mL of a solvent, 1 g – 4 ml to obtain a final concentration of 250 mg of cefoperazone / ml. To reduce pain on intramuscular injections in cases where it is intended to introduce the solution with a concentration of 250 mg / ml or more, it is recommended to use lidocaine for solution (if the patient has no hypersensitivity reaction to lidocaine). This solution may be prepared using sterile water for injection in combination with 2% lidocaine. Consider the following two-step dilution method: first, add the required amount of sterile water for injection and stir until cefoperazone until the powder is completely dissolved, then add the required amount of 2% lidocaine and stir.
Allergic reactions: urticaria, pruritus, maculopapular rash, fever, eosinophilia, erythema multiforme exudative nandrolone (including Stevens-Johnson syndrome), rarely – anaphylactic shock.