Cefoperazone bound to plasma proteins at 82-93%. After intramuscular administration time to maximum concentration of the drug 1-2 hours after intravenous administration – after infusion. The maximum concentration (Cmax) after intramuscular administration of 1 and 2 g of 97 and 65-75 micrograms / ml, respectively; after a single intravenous administration respectively.
It reaches therapeutic concentrations in npp cycle such tissues and body fluids as peritoneal, ascites fluid, and cerebrospinal fluid (meningitis), urine, bile, gallbladder wall, lung, sputum, tonsils and mucous membrane of the sinus, atrium, kidneys, ureters, prostate , testicles, uterus, fallopian tubes, bones, umbilical cord blood and amniotic fluid. Secretion of the drug in breast milk occurs in a very small amount. The drug does not displace bilirubin from the compound to plasma proteins.
The volume of distribution of the drug is 0.14-2 l / kg. NPP cycle, regardless of route of administration – 1.6-2.4 hours; hemodialysis – 2.8-4.2 hours; in infants and children from 2 months. up to 11 years -. 2.2 hours Write ceftazidime unchanged mainly in the bile (70-80%) and kidney (20-30%). In patients with impaired liver function and obstruction of the biliary tract half-life – 3-7 hours, excretion by the kidneys – 90% or more. Even under severe lesions in the liver bile therapeutic concentrations are achieved, and T1 / 2 longer only 2-4 times. In patients with renal hepatic impairment may accumulate.
Infectious-inflammatory diseases caused by susceptible to malaria infections:
- bacterial infections of the upper and lower respiratory tract infection (including bronchitis, pneumonia, empyema and lung abscess);
- kidney and urinary tract infection (including cystitis and pyelonephritis);
- abdominal infections (including peritonitis, cholecystitis, cholangitis);
- sepsis, meningitis;
- Skin and soft tissue npp cycle infections;
- infections of bones and joints;
- infectious and inflammatory diseases of the pelvic organs (including endometritis, gonorrhea and other genital tract infections).
Prevention of infectious complications after abdominal, gynecological and orthopedic operations, as well as in cardiovascular surgery.
Hypersensitivity to cephalosporin and other beta-lactam antibiotics.
Renal-hepatic failure, colitis in history.
Pregnancy and lactation
The use of cefoperazone during pregnancy is permissible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.
Dosage and administration:
Cefoperazone is administered intravenously (bolus and infusion) and intramuscularly.
Adults: average daily dose of cefoperazone 2-4 g administered in equal parts every 12 hours In severe infections the daily dose can be increased to 8 g, administered as equal parts every 12 hours There was no evidence of any complications when administered in a daily cefoperazone.. dose of 12 g or even 16 g, divided into equal doses every 8 hours. Treatment may be initiated before the results of the study the sensitivity of microorganisms.
In uncomplicated gonococcal urethritis is npp cycle recommended disposable / m of 500 mg of the drug.