The ability of sulbactam to prevent the destruction of penicillins and cephalosporins resistant microorganisms has been confirmed in studies using resistant strains, in respect of which sulbactam had pronounced synergism with penicillins and cephalosporins. Furthermore, sulbactam reacted with some penicillin-binding proteins, so cefoperazone / sulbactam often has a stronger effect on strains sensitive than one ceftazidime.
The combination of sulbactam and cefoperazone is npp results active against all organisms sensitive to cefoperazone. In addition, it has a synergy against various microorganisms, particularly..
Cefoperazone / sulbactam is active in vitro against a broad range of clinically relevant microorganisms.
- gram-positive microorganisms
Staphylococcus aureus (producing and not producing penicillinase), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes (beta-hemolytic streptococcus Group A), Streptococcus agalactiae (beta hemolytic Streptococcus group B), most of other strains of beta-hemolytic streptococci, many strains of Streptococcus faecalis ( enterococci).
- Anaerobic microorganisms
Gram-negative bacilli npp results (including Bacteroides fragilis, other Bacteroides species and Fusobacterium spp.).
Gram-positive and Gram-negative cocci (including Peptococcus, Peptostreptococcus and Veillonella spp.).Gram-positive rods (including Clostridium spp., Eubacterium spp. And Lactobacillus spp.).
The following sensitivity levels have been established for cefoperazone / sulbactam. The minimum inhibitory concentration , expressed as cefoperazone concentration for sensitive microorganisms less than or equal to 16, for organisms with intermediate sensitivity is in the range 17-63, and for resistant – more than 64 sensitive areas in determining the disk diffusion method up : for sensitive microorganisms than 21 mm; intermediate sensitivity – 16 to 20 mm and npp results to 15 mm -more resistant.